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Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice

Received: 4 August 2014     Accepted: 11 August 2014     Published: 20 August 2014
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Abstract

This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.

Published in American Journal of Life Sciences (Volume 2, Issue 4)
DOI 10.11648/j.ajls.20140204.13
Page(s) 205-210
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Aspirin, Sperm Malformation, Radioprotection

References
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Cite This Article
  • APA Style

    Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani. (2014). Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. American Journal of Life Sciences, 2(4), 205-210. https://doi.org/10.11648/j.ajls.20140204.13

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    ACS Style

    Marowa Mansour AlMathkour; Entissar Suliman AlSuhaibani. Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. Am. J. Life Sci. 2014, 2(4), 205-210. doi: 10.11648/j.ajls.20140204.13

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    AMA Style

    Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani. Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. Am J Life Sci. 2014;2(4):205-210. doi: 10.11648/j.ajls.20140204.13

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  • @article{10.11648/j.ajls.20140204.13,
      author = {Marowa Mansour AlMathkour and Entissar Suliman AlSuhaibani},
      title = {Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice},
      journal = {American Journal of Life Sciences},
      volume = {2},
      number = {4},
      pages = {205-210},
      doi = {10.11648/j.ajls.20140204.13},
      url = {https://doi.org/10.11648/j.ajls.20140204.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140204.13},
      abstract = {This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice
    AU  - Marowa Mansour AlMathkour
    AU  - Entissar Suliman AlSuhaibani
    Y1  - 2014/08/20
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajls.20140204.13
    DO  - 10.11648/j.ajls.20140204.13
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 205
    EP  - 210
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20140204.13
    AB  - This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • College of Science, King Saud University, Riyadh, Saudi Arabia

  • College of Science, King Saud University, Riyadh, Saudi Arabia

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