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The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis

Received: 6 October 2021     Accepted: 30 October 2021     Published: 5 November 2021
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Abstract

OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.

Published in American Journal of Life Sciences (Volume 9, Issue 5)
DOI 10.11648/j.ajls.20210905.16
Page(s) 141-148
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

OnabotulinumtoxinA, Overactive Bladder, Dosages

References
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Cite This Article
  • APA Style

    Lijun Mu, Enxu Xie, Xinwei Zhang, Juanhua Tian, Meiyu Wang, et al. (2021). The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. American Journal of Life Sciences, 9(5), 141-148. https://doi.org/10.11648/j.ajls.20210905.16

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    ACS Style

    Lijun Mu; Enxu Xie; Xinwei Zhang; Juanhua Tian; Meiyu Wang, et al. The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. Am. J. Life Sci. 2021, 9(5), 141-148. doi: 10.11648/j.ajls.20210905.16

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    AMA Style

    Lijun Mu, Enxu Xie, Xinwei Zhang, Juanhua Tian, Meiyu Wang, et al. The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. Am J Life Sci. 2021;9(5):141-148. doi: 10.11648/j.ajls.20210905.16

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  • @article{10.11648/j.ajls.20210905.16,
      author = {Lijun Mu and Enxu Xie and Xinwei Zhang and Juanhua Tian and Meiyu Wang and Dapeng Wu and Yuefeng Du},
      title = {The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis},
      journal = {American Journal of Life Sciences},
      volume = {9},
      number = {5},
      pages = {141-148},
      doi = {10.11648/j.ajls.20210905.16},
      url = {https://doi.org/10.11648/j.ajls.20210905.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20210905.16},
      abstract = {OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis
    AU  - Lijun Mu
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    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20210905.16
    AB  - OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.
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Author Information
  • Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

  • Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

  • Department of Urology, Xi'an Children’s Hospital, Xi'an, China

  • Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

  • Department of Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

  • Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

  • Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

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