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Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats

Received: 9 May 2015     Accepted: 15 May 2015     Published: 27 May 2015
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Abstract

This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.

Published in American Journal of Life Sciences (Volume 3, Issue 3)
DOI 10.11648/j.ajls.20150303.21
Page(s) 203-212
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Annona senegalensis, Testes, Testicular Function, Histopathology, Rat

References
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  • APA Style

    Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore. (2015). Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. American Journal of Life Sciences, 3(3), 203-212. https://doi.org/10.11648/j.ajls.20150303.21

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    ACS Style

    Charles Obiora Nwonuma; Emenike Onyebum Irokanulo; Adeyemi Eunice Jolaiya; Ayokanmi Ore. Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. Am. J. Life Sci. 2015, 3(3), 203-212. doi: 10.11648/j.ajls.20150303.21

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    AMA Style

    Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore. Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. Am J Life Sci. 2015;3(3):203-212. doi: 10.11648/j.ajls.20150303.21

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  • @article{10.11648/j.ajls.20150303.21,
      author = {Charles Obiora Nwonuma and Emenike Onyebum Irokanulo and Adeyemi Eunice Jolaiya and Ayokanmi Ore},
      title = {Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {3},
      pages = {203-212},
      doi = {10.11648/j.ajls.20150303.21},
      url = {https://doi.org/10.11648/j.ajls.20150303.21},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150303.21},
      abstract = {This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats
    AU  - Charles Obiora Nwonuma
    AU  - Emenike Onyebum Irokanulo
    AU  - Adeyemi Eunice Jolaiya
    AU  - Ayokanmi Ore
    Y1  - 2015/05/27
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.20150303.21
    DO  - 10.11648/j.ajls.20150303.21
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 203
    EP  - 212
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150303.21
    AB  - This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.
    VL  - 3
    IS  - 3
    ER  - 

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Author Information
  • Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria

  • Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria

  • Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria

  • Biochemistry Unit, Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo, Oyo State, Nigeria

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