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Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats

Received: 16 October 2014     Accepted: 27 October 2014     Published: 30 October 2014
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Abstract

Twenty four male rats weighing between 120-130g were randomly assigned into four groups. Group A was fed normal diet; Group B, C and D were fed hypercholesterolemic diet (i.e. 20% fat + 1% cholesterol) for two weeks to establish hypercholesterolemia. Thereafter, Group B were maintained on hyper diet, while C and D were fed 5% and 10% Sesamum indicum seed oil supplemented diet for four weeks. The liver and kidney were removed, dried and powdered. The concentrations of iron, zinc, cobalt, manganese, calcium, potassium, magnesium, potassium and sodium were analyzed in both liver and kidney samples with the use of Atomic Absorption Spectrophotometry. Hypercholesterolemia reduced both the hepatic and renal concentrations of sodium, potassium, Phosphorus, magnesium and calcium but reduced the hepatic and not the renal concentrations of manganese and zinc. Supplementation with 5% but not 10% Sesamum indicum seed oil reversed the effects and restored the reduced ions concentrations. The hepatic and renal concentrations of Iron and Cobalt ions were not affected by hypercholesterolemia nor by supplementation with Sesamum indicum seed oil.

Published in American Journal of Life Sciences (Volume 2, Issue 5)
DOI 10.11648/j.ajls.20140205.19
Page(s) 308-311
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Hypercholesterolemia, Sesamum Indicum, Liver, Kidney, Mineral Concentration

References
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    Ajayi Olubunmi Bolanle, Malachi Oluwaseyi Israel. (2014). Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats. American Journal of Life Sciences, 2(5), 308-311. https://doi.org/10.11648/j.ajls.20140205.19

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    ACS Style

    Ajayi Olubunmi Bolanle; Malachi Oluwaseyi Israel. Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats. Am. J. Life Sci. 2014, 2(5), 308-311. doi: 10.11648/j.ajls.20140205.19

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    AMA Style

    Ajayi Olubunmi Bolanle, Malachi Oluwaseyi Israel. Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats. Am J Life Sci. 2014;2(5):308-311. doi: 10.11648/j.ajls.20140205.19

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  • @article{10.11648/j.ajls.20140205.19,
      author = {Ajayi Olubunmi Bolanle and Malachi Oluwaseyi Israel},
      title = {Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats},
      journal = {American Journal of Life Sciences},
      volume = {2},
      number = {5},
      pages = {308-311},
      doi = {10.11648/j.ajls.20140205.19},
      url = {https://doi.org/10.11648/j.ajls.20140205.19},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140205.19},
      abstract = {Twenty four male rats weighing between 120-130g were randomly assigned into four groups. Group A was fed normal diet; Group B, C and D were fed hypercholesterolemic diet (i.e. 20% fat + 1% cholesterol) for two weeks to establish hypercholesterolemia. Thereafter, Group B were maintained on hyper diet, while C and D were fed 5% and 10% Sesamum indicum seed oil supplemented diet for four weeks. The liver and kidney were removed, dried and powdered. The concentrations of iron, zinc, cobalt, manganese, calcium, potassium, magnesium, potassium and sodium were analyzed in both liver and kidney samples with the use of Atomic Absorption Spectrophotometry. Hypercholesterolemia reduced both the hepatic and renal concentrations of sodium, potassium, Phosphorus, magnesium and calcium but reduced the hepatic and not the renal concentrations of manganese and zinc. Supplementation with 5% but not 10% Sesamum indicum seed oil reversed the effects and restored the reduced ions concentrations. The hepatic and renal concentrations of Iron and Cobalt ions were not affected by hypercholesterolemia nor by supplementation with Sesamum indicum seed oil.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats
    AU  - Ajayi Olubunmi Bolanle
    AU  - Malachi Oluwaseyi Israel
    Y1  - 2014/10/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajls.20140205.19
    DO  - 10.11648/j.ajls.20140205.19
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 308
    EP  - 311
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20140205.19
    AB  - Twenty four male rats weighing between 120-130g were randomly assigned into four groups. Group A was fed normal diet; Group B, C and D were fed hypercholesterolemic diet (i.e. 20% fat + 1% cholesterol) for two weeks to establish hypercholesterolemia. Thereafter, Group B were maintained on hyper diet, while C and D were fed 5% and 10% Sesamum indicum seed oil supplemented diet for four weeks. The liver and kidney were removed, dried and powdered. The concentrations of iron, zinc, cobalt, manganese, calcium, potassium, magnesium, potassium and sodium were analyzed in both liver and kidney samples with the use of Atomic Absorption Spectrophotometry. Hypercholesterolemia reduced both the hepatic and renal concentrations of sodium, potassium, Phosphorus, magnesium and calcium but reduced the hepatic and not the renal concentrations of manganese and zinc. Supplementation with 5% but not 10% Sesamum indicum seed oil reversed the effects and restored the reduced ions concentrations. The hepatic and renal concentrations of Iron and Cobalt ions were not affected by hypercholesterolemia nor by supplementation with Sesamum indicum seed oil.
    VL  - 2
    IS  - 5
    ER  - 

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Author Information
  • Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria

  • Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria

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