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Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis

Received: 19 June 2013     Published: 30 July 2013
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Abstract

Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.

Published in American Journal of Life Sciences (Volume 1, Issue 4)
DOI 10.11648/j.ajls.20130104.14
Page(s) 165-170
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Compound 48/80, Curcumin, Histamine, Mast Cells, Systemic Anaphylaxis

References
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Cite This Article
  • APA Style

    Subhashini, Preeti Singh Chauhan, Sharda Kumari, Debabrata Dash, Rashmi Singh. (2013). Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. American Journal of Life Sciences, 1(4), 165-170. https://doi.org/10.11648/j.ajls.20130104.14

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    ACS Style

    Subhashini; Preeti Singh Chauhan; Sharda Kumari; Debabrata Dash; Rashmi Singh. Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. Am. J. Life Sci. 2013, 1(4), 165-170. doi: 10.11648/j.ajls.20130104.14

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    AMA Style

    Subhashini, Preeti Singh Chauhan, Sharda Kumari, Debabrata Dash, Rashmi Singh. Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. Am J Life Sci. 2013;1(4):165-170. doi: 10.11648/j.ajls.20130104.14

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  • @article{10.11648/j.ajls.20130104.14,
      author = {Subhashini and Preeti Singh Chauhan and Sharda Kumari and Debabrata Dash and Rashmi Singh},
      title = {Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis},
      journal = {American Journal of Life Sciences},
      volume = {1},
      number = {4},
      pages = {165-170},
      doi = {10.11648/j.ajls.20130104.14},
      url = {https://doi.org/10.11648/j.ajls.20130104.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20130104.14},
      abstract = {Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.},
     year = {2013}
    }
    

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  • TY  - JOUR
    T1  - Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis
    AU  - Subhashini
    AU  - Preeti Singh Chauhan
    AU  - Sharda Kumari
    AU  - Debabrata Dash
    AU  - Rashmi Singh
    Y1  - 2013/07/30
    PY  - 2013
    N1  - https://doi.org/10.11648/j.ajls.20130104.14
    DO  - 10.11648/j.ajls.20130104.14
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 165
    EP  - 170
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20130104.14
    AB  - Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.
    VL  - 1
    IS  - 4
    ER  - 

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Author Information
  • Department of Zoology, MMV, Banaras Hindu University, Varanasi, India

  • Department of Zoology, MMV, Banaras Hindu University, Varanasi, India

  • Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

  • Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

  • Department of Zoology, MMV, Banaras Hindu University, Varanasi, India

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